Abstract
A new, simple, rapid and sensitive spectrophotometric method for the determination of sulfamethoxazole in both pure form and pharmaceutical preparations has been reported.The adapted technique based on utilization 4-aminobenzene sulfonic acid as a new modern chromogenic through an oxidative coupling reaction with sulfamethoxazole and potassium iodate in basic media to form orange soluble dye product with absorption maxima at 490 nm. Subject to Beer's law in the range 2–32μg mL-1. The values of molarabsorption coefficient (ε) and correlation coefficient were found to be 9.118 × 103 and0.9999 respectively whereas the Sandels index was 0. 02778 µg.cm-2
Highlights
Sulfamethoxazoloe (SMZ) is an isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position
The adapted technique based on utilization 4-aminobenzene sulfonic acid as a new modern chromogenic through an oxidative coupling reaction with sulfamethoxazole and potassium iodate in basic media to form orange soluble dye product with absorption maxima at 490 nm
Many reagents were used as an oxidative coupling for this drug
Summary
Sulfamethoxazoloe (SMZ) is an isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position. It has a role as an antibacterial agent. After being introduced in the United States in 1960 (Amaliet al.,2019),it is mostly used in combination with trimethoprim, abbreviated as (SMZ-TMP) (Bruntonet al., 2011). This combination (formulation) is included registered in WHO model list of essential medicines as a prime choice treatment for urinary tract infection. The system used by the Bratton and Marshall was considered to be the most popular colorimetric method used for sulfa drugs (Zhou et al, 2009)
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