Abstract
The purpose of the research was to study the role of the angiogenic system in the pathogenesis of the luteal phase insufficiency in women in reproductive age with primary oligomenorrhea in the pubertal period. In a comparative aspect with healthy women (the control group), the hemodynamics in the ovarian arteries and in the arteries of the ovarian stroma in 30 women in reproductive age with primary oligomenorrhea in the pubertal period (the study group) was studied. The angiogenic system was studied by the indices of the vascular endothelial growth factor (VEGF) and its receptor (VEGFR1) in the blood serum. It was found out that in 10 women of the studied group the ovulatory menstrual cycle was accompanied by luteal phase insufficiency; the serum progesterone concentration was 1.7 times lower (27.41±3.10 nmol/L) than in the control group (47.64±4.19 nmol/L, p<0.001). In women with luteal phase insufficiency, the VEGF concentration (11.17±6.18 pg/ml) and the angiogenic coefficient of VEGF/VEGFR1 (0.76) were 2 times lower than in the control group (209.06±20.41 pg/ml; 1.52) and in women with primary oligomenorrhea in the pubertal period with a full luteal phase (237.98±24.67 pg/mL; 1.44). The blood flow velocities in the ovarian artery and in the vessels of the ovarian stroma with the dominant follicle did not differ from the parameters of the opposite ovary and were lower in comparison with those of the control group. A model for predicting the formation of a functionally active yellow body has been developed. Thus, the reduction of the angiogenic potential and imbalance in the angiogenic ovary system with a dominant follicle is one of the links in the pathogenesis of luteal phase insufficiency in women in reproductive age with primary oligomenorrhea in the pubertal period. 2 times increase of the VEGF concentration and of angiogenic coefficient by more than 1.0 provides adequate angiogenesis in the dominant follicle and the formation of a full-valued yellow body.
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