Аутосомные локусы STR, вовлечённые в исключение при экспертизе родства в популяции Тюменской области

Abstract

Aim. To conduct an analysis of STR-loci in cases of exclusion during the paternity expertise, analyze the distribution of their frequencies. Materials and methods. 364 paternity expertises (non-exclusion and exclusion) were studied, in which a molecular genetic study of the blood of all participants was carried out by the method of capillary electrophoresis. Results. Paternity was excluded out of 364 examinations in 72 cases. Of these, in 68 cases, samples for research were taken from the mother, the alleged father and the child. Groups I and II were formed. Group I included examinations in which both the mother and the child were born in the Tyumen region (53 cases). Group II included examinations in which either the mother or the child was born outside the Tyumen region (15 cases). The frequency of distribution of the loci involved in exclusion and the most frequent alleles among those found were determined. Conclusion. It was found that the role of a locus in exclusion cases does not directly depend on its polymorphism and / or frequency of mutations. Establishing the loci most often involved in excluding kinship allows the use of predominantly such more informative loci or panels containing such loci when investigating kinship in a particular geographic locality.