Полиморфный вариант rs10830963 гена рецептора мелатонина 2 типа и параметры сердечного ритма у мужчин с разным типом физической нагрузки

Abstract

Objective. The cardiovascular system demonstrates daily periodic changes in heart rate and blood pressure. Melatonin is involved in the regulation of the cardiovascular system by modulating sympathetic function and signaling pathways associated with nitric oxide (NO), as well as through interactions with its receptors. The aim of the study was to study the distribution of the allele frequency of the rs10830963 MTNR1B polymorphic marker gene in healthy donors, as well as to search for a relationship between variants of this gene and heart rate parameters in healthy donors with different types of exercise. Materials and methods. Study design – cross-sectional, non-randomized. The study included 80 healthy donors with various types of physical activity, as well as a control group made up of men leading a sedentary lifestyle. Venous blood samples from donors were used for DNA isolation. The polymorphism of the polymorphic marker rs10830963 of the MTNR1B type melatonin receptor gene was studied by PCR. Heart rate parameters were assessed using the Poly-Spectrum-8 / E software and hardware complex (Neurosoft, Russia) according to the generally accepted method. Results. Significantly low values of muscle mass in the control group are shown in comparison with donors of strength specialization. No associations were found between the polymorphic marker rs10830963 of the MTNR 1B gene and deviations from normal body weight and BMI, as well as parameters of heart rate variability in the studied donors. Conclusion. The rs10830963 polymorphic marker of the MTNR 1B gene is not associated with BMI and heart rate parameters of healthy donors. This sample of examined patients (less than 100 people) does not allow to reliably estimate the parameters of the heart rate in donors with a certain type of physical activity and carriage of a certain allele rs10830963 of the MTNR1B gene.