Перспективы применения N-ацетилцистеина в качестве нефропротектора у пациентов с сочетанной травмой и другие фармакологические аспекты клинического использования данного вещества

Abstract

Summary. Objectives of the study were to analyze a wide range of published data; to study biological activity and bioavailability of N-acetylcysteine (N-AC) as well as a possibility of using the drug in clinical practice to eliminate oxidative stress and inflammatory reactions in pathological conditions and nosologies; to study its therapeutic effectiveness in renal dysfunction in patients with concomitant trauma. Study materials and methods. Materials of research: scientific publications on the specified problems. Research method: analytical. Results of the study and their analysis. A review of domestic and foreign literature on the role of N-acetylcysteine in correction of oxidative stress and protection against free radicals is presented. The great role of N-acetylcysteine for the replenishment of the intracellular content of glutathione, the main cellular antioxidant, as well as the potential possibility of using N-acetylcysteine in clinical practice for various pathologies and diseases is investigated. Review of the results of a large number of studies leads the authors to the conclusion that this pharmacological substance is a very promising means for replenishing the intracellular content of glutathione and can be used in the treatment of a number of diseases.