비중격 성형술에서 Morniflumate, Paracetamol, Pregabalin의 통증 조절 효과 비교

Abstract

Background and Objectives: Septoplasty is a common otolaryngological procedure. Patients who undergo septoplasty frequently complain of pain in the early postoperative period due to surgical trauma and nasal packing. The oral analgesics morniflumate (a nonsteroidal anti-inflammatory drug [NSAID]), paracetamol, and pregabalin are commonly used to control pain after septoplasty. We compared the efficacy of these analgesics in controlling postoperative pain. Materials and Methods: The study included 44 male patients who underwent septoplasty due to nasal septal deviation. The patients received morniflumate (350 mg twice daily, n=15), paracetamol (650 mg three times daily, n=14), or pregabalin (75 mg twice daily, n=15), and postoperative pain was assessed for 3 days after surgery. Results: The postoperative pain decreased significantly over the observation period despite the type of analgesic administered. Although morniflumate was the most effective, followed by paracetamol and pregabalin, the differences were not statistically significant. Conclusions: We found no significant differences in efficacy among the three analgesics most commonly prescribed for postoperative pain after septoplasty. (J Clinical Otolaryngol 2019;30:49-54)