Роль гистондеацетилаз I и IIa (HDAC1, HDAC4/5) и сигнального пути MAPK38 в регуляции атрофических процессов при функциональной разгрузке скелетных мышц

Abstract

Various forms of muscle unloading can be found in patients with prolonged bed rest, with strokes and spinal lesions, during muscle immobilization in traumatology, in zero gravity, etc. During unloading, basically, postural muscles (for example, soleus) are affected. The rearrangement of skeletal muscles during unloading is based on their atrophy due to an increase in proteolysis and a decrease in the intensity of protein synthesis [1, 2]. The review is devoted to the study of the histone deacetylases I and IIa (HDAC1, HDAC 4/5) role, as well as the MAPK38 signaling pathway in the activation of transcription factors FOXO and myogenin, which are involved in the expression of E3 ubiquitin ligases genes atrogin-1 and MuRF-1 under skeletal muscle unloading.