Abstract
Basophils and mast cells play an important role in FceRI-mediated allergic reaction as effector cells. We studied the effects of Acanthopanax chiisanensis on FceRI α chain expression in human basophilic KU812F cells. Ethanol extracts from root and stem of A. chiisanensis were tested for inhibitory effects of FceRI α chain expression. The cell surface FceRI α chain expression was examined by flow cytometric analysis. All of the extracts of A. chiisanensis reduced the cell surface FceRI α chain expression. Furthermore, A. chiisanensis extracts caused a decrease in the level of FceRI α chain mRNA level and FceRI-mediated histamine release. These results suggest that root and stem extracts of A. chiisanensis play an important role in anti-allergic activity via down-regulation of FceRI α chain expression and decrease in release of inflammatory mediator such as histamine.
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