Abstract
AbstractUse of the hypervalent aryl‐λ3‐iodane reagent iodobenzene dichloride (PhICl2) in the α‐carbonyl dichlorination of 2‐oxindoles is reported. Treating a series of diversely substituted 3‐diazo‐2‐oxindoles with PhICl2 in the presence of pyridine, a Lewis base iodane‐activator, results in 3,3‐dichloro‐2‐oxindole products. Activation of PhICl2 is key to the chlorination proceeding rapidly, chemoselectively and in good to excellent yields. This investigation represents a novel approach to the synthesis of 3,3‐disubstituted‐2‐oxindoles, and illustrates the compatibility of the ligand‐transfer reaction with the 2‐oxindole scaffold.magnified image
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
