β,β-Dialkyl γ-amino γ-trifluoromethyl alcohols from trifluoromethyl (E)-aldimines by a one-pot solvent-free Mannich-type reaction and subsequent reduction

Abstract

A diastereoselective one-pot solvent-free Mannich-type addition of α-alkyl aldehydes to trifluoromethyl (E)-aldimines, which first act as bases and then as electrophiles, leads to β,β-dialkyl γ-amino γ-CF3 alcohols in good yields, after reduction.