당뇨 마우스에서 cyanidin-3-O-glucoside의 식후 고혈당 완화 효과

Abstract

Cyanidin-3-O-glucoside (C3G) shows anti-inflammatory and antioxidant effects; however, its effect on postprandial blood glucose levels remains unknown. Alpha-glucosidase inhibitors regulate postprandial hyperglycemia by impeding carbohydrate digestion in the small intestine. Here, the effect of C3G on α-glucosidase and α-amylase inhibition and its ability to ameliorate postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice were evaluated. ICR normal and STZ-induced diabetic mice were orally administered soluble starch alone or with C3G or acarbose. The half-maximal inhibitory concentrations of C3G for α-glucosidase and α-amylase were 13.72 and 7.5 μM, respectively, suggesting that C3G was more effective than acarbose. The increase in postprandial blood glucose levels was more significantly reduced in the C3G groups than in the control group for both diabetic and normal mice. The area under the curve for the diabetic mice was significantly reduced following C3G administration. C3G may be a potent α-glucosidase inhibitor and may delay dietary carbohydrate absorption.