Abstract
Abstract. Introduction. Since the early 1980s, the world has experienced an epidemic of human immunodeficiency virus infection. After that, in 2019 healthcare system faced a pandemic of infection caused by the emergence of a new coronavirus SARS-CoV-2, which caused high morbidity and mortality worldwide. Data on the incidence, course, and outcomes of COVID-19 in people living with human immunodeficiency virus are limited. Aim. The aim of the study is to examine data from publications on clinical outcomes of COVID-19 in people living with human immunodeficiency virus. Material and methods. A thorough literature search was carried out using the MEDLINE, Embase, Scopus databases, 21 sources were selected and analyzed. Results and discussion. Publication data do not indicate that people living with human immunodeficiency virus are more susceptible to COVID-19 than the general population. As in the general population, older age and the presence of comorbidities worsen the prognosis in patients with human immunodeficiency virus and COVID-19. A number of authors note higher mortality rates from COVID-19 infection in HIV-infected patients of African and Asian descent. Well-controlled human immunodeficiency virus infection does not change the clinical presentation or worsen the clinical outcome of hospitalization for COVID-19 infection in HIV-infected patients. Patients with human immunodeficiency virus in the advanced stages of the disease may show less severe symptoms of COVID-19 infection due to a reduction in the severity of immune responses. Conclusion. Clinical outcomes of COVID-19 in patients with and without human immunodeficiency virus coinfection are comparable. The high-risk group for COVID-19 includes human immunodeficiency virus patients with pre-existing comorbidities and individuals in older age groups. Controlled human immunodeficiency virus patients with an undetectable viral load have a better prognosis than uncontrolled patients.
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