건강기능식품 원료 Bifidobacterium breve IDCC 4401 열처리배양건조물의 혈중 콜레스테롤 개선 기능성에 관한 고찰

Abstract

Blood cholesterol is an item of national health examinations in Korea, which is one of the essential health indicators that healthy and semi-healthy people, who are not in the stage of taking medicine, also need to be managed by controlling their lifestyle. HMG-CoA reductase inhibitors, which are commonly used to lower blood cholesterol, have been reported to have various adverse events, and there are several factors limiting their application. As a result, semi-healthy and healthy people who do not have critical health issues may not be able to take these drugs. Bifidobacterium breve IDCC 4401 heat treatment culture powder (BBR4401) is a functional raw material obtained by heat-treating and killing the probiotic Bifidobacterium breve which is widely used as a functional raw material for improving intestinal health in foods and health functional foods. In addition, BBR4401 is a raw material with safety and stability which has been recognized for its cholesterol-improving functionality. Therefore, healthy and semi-healthy people who wish to manage their blood cholesterol can consume BBR4401 for prevention/management purposes. Furthermore, BBR4401 has an entirely different mechanism of action from HMG-CoA reductase inhibitors in that it inhibits the reabsorption of cholesterol/bile acids in the small intestine, meaning that even those who are taking HMG-CoA reductase inhibitors can consume BBR4401 to manage their blood cholesterol; this treatment combination is expected to provide a synergic effect in improving cholesterol.