Abstract
Given the complexity of studying neurocognitive functions and the mechanisms underlying their normal functioning, and the causes that lead to disorders of these functions, the relevance of laboratory animal models in biomedical research is of decisive importance in the light of the possibility of obtaining valuable data with their help. Based on advances in genetic engineering, various transgenic, knockout animal models have been created, leading to important discoveries in this field. Here we present a preliminary experimental data obtained on an existing animal model involving an important regulatory system - the system of dopaminergic neurotransmitters. In the future, new knowledge obtained on DAT knockout rats may help elucidate the etiology of neurocognitive disorders and the exact mechanisms of their development.
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