Герпесвирусы. Часть 2

Abstract

The clinical manifestations of herpes infection depend on the pathogenic properties of the pathogen and on the state of immunity of the infected organism. Herpesviruses type 1-3 are predominantly neurotropic and cause diseases of the nervous system. The reproduction of the virus is carried out in the neurons of the nerve ganglia and epithelial cells, as they have a common ectodermal origin. Herpesviruses type 4, 5 and 8 are predominantly lymphotropic and cause diseases of the immune system. In a latent and persistent state, viruses are found in lymphocytes, monocytes, polymorphonuclear leukocytes, as they exhibit tropism for cells of mesenchymal origin. When the infection is reactivated, the virus is reproduced in cells of ectodermal origin, which leads to characteristic organ lesions. Type 6 and 7 viruses are both neurotropic and lymphotropic. They are capable to infect T-lymphocytes, B-lymphocytes, epithelial cells, endothelial cells, hepatocytes, fibroblasts, glial cells, stem cells, monocytes, macrophages, leukocytes, etc. They are able to promote the reactivation of other viruses, forming mixed forms, which leads to an aggravation of the clinical picture of the disease. Therapy of herpesvirus infections should be scientifically grounded, consistent, gradual, complex and include: specific antiviral treatment; immunotherapy; antibacterial therapy; detoxification therapy; symptomatic treatment and therapeutic measures aimed to eliminate various complications. Antiviral drugs for the treatment of herpes infection are divided into 4 groups: nucleoside analogs; drugs that cause the destruction of viruses located extracellularly; drugs that are active against intracellular viruses; drugs with a double effect. Modern therapy of herpesvirus infections is capable to suppress the reproductive activity of the reactivated virus, modulate the body's immune response, prevent and eliminate various complications of herpes infections, but is unable to affect the latent form of viruses. In the complex therapy of herpes infection, along with the specific treatment methods aimed to destroy the virus and to enhance the body's immunity, it is necessary to apply the entire range of therapeutic measures that help eliminate the accompanying symptoms and complications of diseases caused by herpesviruses