고혈압을 동반한 제2형 당뇨병 여성노인의 복합운동이 심혈관 위험인자, 8-OHdG 및 SOD에 미치는 영향

Abstract

Purpose: The purpose of this study is to investigate the effects of combined exercise on cardiovascular risk factors, 8-hydroxy-2′-deoxyguanosine and superoxide dismutases in elderly women with type 2 diabetes mellitus with hypertension.<BR> Method: The subjects were thirty type 2 diabetes elderly women with hypertension volunteers, aged 65 to 80 years, composed of the exercise group (n=18) and control group (n=12). The combined exercise program (60 min) consisted of moderate-intensity (RPE 5~6), walking exercise and progressive-intensity (1-4 weeks: OMNI-RES 3~4, 5-8 weeks: OMNI-RES 5~6, 9-12 weeks: OMNI-RES 7~8) elastic band exercise. This was performed 3 times per week for 12 weeks.<BR> Results: Cardiovascular risk factors were found to have a significant interaction effect on systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, and atherogenic index. In addition, the interaction effect was found to be significant in 8-OHdG and SOD. Results of the exercise group were as follows; systolic blood pressure (p<.001), diastolic blood pressure (p<.001), triglyceride (p<.05), atherogenic index (p<.001), and 8-OHdG (p<.05) had significantly decreased. high-density lipoprotein cholesterol (p<.001) and SOD (p<.05) had significantly increased. Changes in SOD were negatively correlated with changes in 8-OHdG (p<.05), triglycerides (p<.05) and Log (TG/HDL-C) (p<.01), and were positively correlated with the change of high-density lipoprotein cholesterol p(<.05). SOD influenced 8-OHdG (p<.05), and Log (TG/HDL) influenced SOD (p<.001).<BR> Conclusion: In type 2 diabetes mellitus with hypertension, 12 weeks of combined exercise had a positive effect on the reduction of atherogenic index by lowering blood pressure, improving triglycerides and high-density lipoprotein cholesterol. It is thought to be effective in reducing DNA oxidative damage by increasing antioxidant enzymes. Therefore, the importance of combined exercise is emphasized for cardiovascular health by strengthening the antioxidant defense system and reducing oxidative damage according to lipid improvement in high blood pressure and type 2 diabetes at high risk of cardiovascular disease exposure.