Abstract
ABSTRACT Objectives : Recently there have been encouraging results, from a western perspective, in the cancer research field regarding the anticancer effects of herbal medicine. This paper was aimed to review herbal medicine playing its anticancer role in terms of apoptosis, inflammation control, differentiation and telomerase.Methods : New studies for tang, medicinal herb itself or effective ingr adients of medicinal herb showing anti-cancer effectiveness were reviewed and summarized in terms of pharmacological action.Results : Ethanol extracts of Spatholobus suberectus greatly inhibited cancer cell growth inducing cell apoptosis and cytotoxic effects. Scutellaria baicalensis may be responsible for its anticancer activity showing inhibit ion of PGE 2 synthesis via suppression of COX-2 expression. Saikosaponins i solated from Bupleurum induced the differentiation of C6 glioma cells, cancer cells, into astrocyt es, normal cells. Acetone extract of Bupleurum scorzonerifolium inhibited proliferation of human lung cancer cells via inducing apoptosis and suppressing telomerase activity.Conclusions : Herbal medicine inhibited cancer cell growth inducing cell ap optosis and cytotoxic effects. Inflammation persisting for a decade eventually elevates the ri sk of cancer sufficiently that it is discernible in case control epidemiological studies. Differentiation therapy i s defined as a therapy to treat cancers by inducing differentiation of the stem cells. Telomerase expression is a h allmark of cancer. Nearly the complete spectrum of human tumors has been shown to be telomerase positive.Key words : Korean traditional medicines ; anti-cancer; apoptosis; infla mmation; differentiation therapy
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