Abstract
We clinically used thawed red blood cell concentrates during cardiac surgery, after we experimentally recognized Poloxamer 188 to reduce serum free hemoglobin level in the extracorporeal circulation using thawed red blood cell concentrates. We primed extracorporeal circuit by thawed red blood cell concentrates, Poloxamer 188 and usual other solutions (subject group, N=8). The examinations of the serum free hemoglobin level and other serum chemistries were investigated postoperatively. The serum free hemoglobin level and the hemolysis starting point of osmotic fragility test of erythrocytes with coil planet centrifuge method were comparatively higher level (65.6±18.5mg/dl, 102.1±4.3mOsm.) immediately after operation than control group (cases using fresh whole blood), although returned normal level after one postoperative day. And renal failures due to hemolysis were not seen in both groups. The postoperative liver dysfunction was recognized 3 cases in control group, but none in subject group.We concluded that the extracorporeal circulation using Poloxamer 188 and thawed red blood cell concentrates will be usefull to minimized the hemolysis and the infection by blood transfusions and that smooth blood supply will be expected at a time of the emergent operation by using thawed red blood cell concentrates.
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