Abstract
Wc have succeeded in transplanting human osteogenic sarcoma of the mandible into nude mice. As the transplanted tumor shows features of calcified chondrosarcoma, this tumor is thought to be an excellent model for study of the process of endochondral calcification.Using this model, we studied relations between the expression of types II, and X collagen and chondrogenic differentiation of the transplanted tumor. Collagen distribution during the development and growth of the transplanted tumor was investigated by immunofluorescence with specific antibodies against type I, II, or X collagen.Type I collagen was localized in the peripheral region of the tumor, though it disappeared in the mineralizing region. Type II collagen was distributed in the premineralizing region where tumor cells showed chondrocytic or hypertrophic feature. Type X collagen was intensely stained in the mineralizing region. Tumor cells in this region were almost. hypertrophic.These results indicate that the type of collagen changes from type 11 to type x in the hypertrophic region and the appearance of type X collagen may be important in the onset of mineralization.
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