Abstract
The stabilities and the release of hydrocortisone-17-butyrate (HC-17-B), fluocinonide (FLC), amcinonide (AMC), beclomethasone dipropionate (BCM-DP), triamcinolone acetonide (TCA), betamethasone dipropionate (BM-DP) and betamethasone valerate (BM-V) in admixtures of commercial ointment with boric acid and zinc oxide ointment (BZO) were studied. Determination of several corticosteroids were made by high-performance liquid chromatography.The stabilities were recorded immediately after admixing and after storage for 2, 4, 8 and 12 weeks at 5°C, 25°C and 40°C. FLC, AMC, BCM-DP and BM-DP were stable in all cases, but after storage for 12 weeks at 40°C, 88.4% of BM-V, 88.6% of TCA and 31.2% of HC-17-B remained in the admixtures. The amounts of all corticosteroids released from commercial ointments admixed with BZO were greater than those from the individual commercial ointments.
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