Abstract
A case of proliferative verrucous leukoplakia (PVL) in the oralmucosa of a 67-year-old woman is reported. PVL was first described in 1985 as an unique type of oral leukoplakia that has a high risk of malignant transformation. In our patient, the initial lesion was hyperkeratosis associated with mild dysplasia of the buccal mucosa. This condition recurred repeatedly and spread to the upper and lower gingivas, lower lip, and palate. The lesions changed to verrucous hyperplasia and finally developed into verrucous carcinomas. The patient was not cured of the disease, though she received surgical excision 6 times over a period of 7 years 10 months. She died of rupture of a thoracic aortic aneurysm. Immunohistochemical staining for human papillomavirus type 16 (HPV16)-related protein was positive in the epithelial cells of the lesions, suggesting that HPV16 was involved in the pathogenesis of PVL.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Japanese Journal of Oral & Maxillofacial Surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
