Abstract
Novel methodologies for stereocontrolled synthesis of 2, 6-dideoxy sugars by efficient use of 2, 6-anhydro-2-thio sugar and its application to synthesis of natural products are described. This article involves highly stereocontrolled and powerful glycosylations of 2, 6-anhydro-2-thio sugar for synthesis of 2, 6-dideoxy-α- and β-glycosides and highly sterecontrolled creations of C-3 configuration of 2, 6-dideoxy sugar by an addition of a nucleophilic reagent to 2, 6-anhydro-2-thio sugar. Further, the efficient total synthesis of erythromycin A, which is a most typical and clinically important macrolide antibiotic, from (9S) -9-dihydroerythronolide A is achieved by the successful application of the present novel methodologies.
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