Abstract
Peripheral blood lymphocytes from patients with lingual or maxillary cancer (well differentiated squamous cell carcinoma) were mixed allogeneic tumor cell line originated maxillary squamous cell carcinoma, and further activated with recombinant interleukin 2 (rIL2) to induce autologous tumor killing lymphoid cells (AlloTLAK). AlloTLAK was infused back to the patients directly into lingual or maxillar artery. Results indicated a significant primary effect on reduction of tumor mass in the both cases. Tumor size of lingual cancer was markedly reduced from 55mm to 18mm diameter by 4 times infusions of AlloTLAK. Tumor of maxillary cancer staged as T3 was completely disappeared by 10 times infusions of AlloTLAK, and at least the surgical operation became unneccessary in this case. The case with lingual cancer received surgical operation to remove 1/3 of the tongue with radical neck dissection, and the tissues were histologically examined. Histological findings proved marked anti tumor effect of AlloTLAK demonstrating strong degeneration of the tumor cells with infiltration of lymphocytes and scavenger macrophages. Side effects were minor, such as slight fever and blood eosinophilia, which may be due to the rIL2 function
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