Abstract
Routinely formol-fixed and paraffine-embedded surgical spacimens of either the palatine tonsil or upper pharynx from 75 patients, which was replaced by the following respective foci: 24 squamous cell carcinoma, 20 non-Hodgkin's malignant lymphomas, 3 metastatic carcinomas, each one of 5 nonhematopoietic cell tumors, 19 chronic inflammatory changes, and 4 cases doubted in the first biopsies whether malignant lymphoma or undifferentiated carcinoma, were stained immunohistologically with anti-LCA and anti-EMA sera, respectively.All of the examined malignant lymphoma cells and non-neoplastic lymphoid cells were definetely immunoreactive for LCA, but not for EMA. On the other hand, the examined carcinoma cells and nonhematopoietic tumor cells were completely negative for LCA. Doubted 4 cases could be diagnosed as 3 malignant lymphomas and 1 undifferentiated carcinoma in the following biopsies. The former 3 cases were immunoreactive for LCA and lacked immunoreactivity for EMA. The latter was positive for EMA, but negative for LCA. In conclusion, the immunohistological stain for LCA was useful to the diagnostic discrimination between lymphatic and nonhematopoietic tumors, especially between non-Hodgkin's malignant lymphoma and undifferentiated carcinoma in the upper and middle pharyngeal regions, although the grade of expression for LCA was heterogeneous in the same sections.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
