耳鼻咽喉科急性感染症における耐性菌の検討 ＰＲＳＰ，ＢＬＮＡＲを中心として

Abstract

In recent years, increased incidences of penicillin-resistant Streptococcus Pneumoniae (PRSP) strains and β-lactamase-negative ampicillin-resistant (BLNAR) Haemophilus influenzae strains have been reported. We performed bacteriological studies on 29 Streptococcus Pneumoniae strains and 26 Haemophilus influenzae strains that were isolated in our outpatient department between September 1998 and August 1999.The mean age of patients from whom bacteria were isolated was 7.3 years, while 14 of the Streptococcus Pneumoniae strains and 15 of the Haemophilus influenzae strains were isolated from patients under the age of 2 years.The 29 Streptococcus Pneumoniae strains included 11 (37.9%) penicillin-insensitive strains (PISP) and 10 (34.5%) PRSP. The combination of PISP and PRSP strains thus accounted for 72.4% of the total Streptococcus Pneumoniae isolates. Those PISP and PRSP strains were exposed to various oral antibacterial agents, and FRPM, CDTR and CFPN showed excellent antibacterial activity. The 26 Haemophilus influenzae strains did not include any β-lactamase producers, but 14 (53.8%) BLNAR strains were detected, representing a high frequency. Among the tested oral antibacterial agents, CDTR and CFPN showed excellent antibacterial activity against the BLNAR strains. FRPM showed an excellent MIC distribution in relation to the Streptococcus Pneumoniae strains, but its MICs for the Haemophilus inf luenzae strains were high.Among the currently used oral antibacterial agents, CDTR and CFPN showed excellent MICs for both the PRSP and BLNAR strains.