糖尿病を合併した新鮮ＮＢｅｌｌ麻ひの臨床的検討 ｓｔｅｒｏｉｄ療法とｌｉｐｏ ＰＧＥ１療法の比較検討

Abstract

This study was designed to compare large dose steroid therapy and lipo-PGE1therapy in 22 previously untreated patients with Bell's palsy accompanied by diabetes mellitus. Thirteen patients were treated with large dose steroid therapy, while the remaining 9 were treated with Lipo-PGE1 therapy. No significant differences in patient backgrounds, such as age, sex, and the side of palsy, were present between the two treatment groups. Furthermore, no significant differences in the mean palsy score at the time of presentation or at the time of aggravation were present between the two groups. Cumulative recovery rates after treatment did not differ significantly at 4 weeks or at 2 and 6 months between the two groups, nor were there any differences in the therapeutic outcomes between the groups. Fasting blood glucose levels during the period of treatment were elevated in all 13 patients receiving steroids, but not in the lipo-PGE1 group. Diabetes mellitus was also aggravated in the steroid group, but not in the lipo-PGE1 group. These findings indicate that lipoPGE1 therapy improves the blood flow to facial nerves, promoting recovery from Bell's palsy. Furthermore, lipoPGE1, therapy is useful for the treatment of Bell's palsy accompanied by diabetes mellitus because it has the same recovery rate as that of large dose steroid therapy, but it does not aggravate diabetes mellitus.