ベクロメタゾン点鼻剤の鼻腔内分布の検討 呼吸状態，鼻腔内形態の影響

Abstract

Although betamethasone (BTM) nose drops have been the most common treatment for olfactory dysfunction, only a few reports are available in regard to the distribution of this drug by this mode. From the point of view of delivery to the olfactory cleft, the spray form may be a feasible alternative. In order to establish the treatment of olfactory dysfunction by beclomethasone (BCM) spray, the authors examined its distribution in a silicon replica prepared from a mold of a cadaver nasal cavity, available from Koken Co. Ltd., which was used as such and also modified by dental paste to simulate septal deformity or nasal polyp. The effects of respiration on drug delivery were also examined. Nine pieces of 8 mm square filter paper were placed on different sites of the replica. After the application of BCM spray or BTM nose drops, the concentrations of each drug on the filter paper squares were determined by HPLC. A larger concentration of BCM spray than of BTM drops was present even in models with deviation or nasal polyp, if the olfactory cleft remained open. In addition, there was no difference in amount of BCM delivered into the holding olfactory cleft between conditions of simulated inspiration and of breath. During inspiration, more BCM spray entered the upper pharynx, although the instructions for the use of BCM suggest that the spray should be inhaled. The amounts of BCM in the anterior nasal cavity and nasal fissures were increased when applied in the upward direction. Our results suggest that BCM spray can be used in the treatment of olfactory dysfunction.