Abstract
For clinical application of Ceftriaxone (CTRX) in the oral field, a pharmacokinetic analysis was performed for CTRX concentration in the oral tissues and dose of 1g CTRX was administered to 37 patients in one shot by intravenous injection.The following results were obtained.1) The half life of CTRX in serum was thus calculated to be 7.412 hour.2) The highest concentrations of CTRX were 39.5μg/g in the gum, 19.0μg/g in the bone and 45.7μg/g in the cyst wall. The half life of CTRX was 4.09 hours in the gum, 2.26 hours in the bone and 7.29 hours in the cyst wall.The above results suggest that CTRX had the most favorable affinity of cephem antibiotics in the oral tissues.
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