鼻アレルギーにおけるキヌ抗原の臨床的意義の検討 チョウ，ガのりん粉アレルギーとの関連性について

Abstract

So-called silk extract is made from the cocoon of the silkworm (shell and chrysalis). In our department, 12% of the patients with allergic rhinitis had a positive intradermal skin test with silk extract, and almost all of them showed a positive response to house dust extract as well. The RAST was used on sera of 75 cases of allergic rhinitis to determine cross-antigenicity between silk antigen and mite antigen, which is the main component of house dust antigen. No cross-antigenicity was detected. Cross-antigenicity between silk antigen and extract from the scales of the silkworm moth was tested in the same way with sera of 19 cases containing IgE antibody to both antigens. Cross-antigenicity was high. The coincidence rate (68%) between the result of the skin test with the silk extract and the silk RAST was rather lower than that (89%) between the result of the skin test with the scale extract and the silk RAST. This may be due mainly to the low concentration of antigen in the silk extract. Fourteen percent of the patients with allergic rhinitis who consulted us between September 1982 and August 1983 had positive skin tests with the scale extract, and they comprised 22% of the house-dust-positive patients. Seventy one percent of the patients with a positive silk RAST test lived in green areas, such as woods, fields and farms, while only 49% of the negative group did so. These results and other reports suggested that the silk positive patients were sensitized by contact with antigens of moths or butterflies rather than silk products, but trials to investigate the influence of the silk antigen on symptoms of allergic rhinitis had little success.