ПЕРВИЧНАЯ ПРОФИЛАКТИКА ДЕМЕНЦИИ

Abstract

Every year there is an increase of almost 10 million cases of dementia worldwide. This disease is the seventh leading cause of death in the world and is one of the leading causes of disability in older people. Minimizing the pathological (social and economic) impact of dementia on society is based on improving the primary prevention model. Currently, there is an increase in evidence-based data on the harmful effects of potentially modifiable factors that can induce neurodegenerative diseases. The article contains information about hyperepithelial permeability syndrome, which leads to increased circulation of lipopolysaccharides; it is concluded that “dysbiosis” contributes to the development of neurodegenerative and neuroinflammatory changes in the central nervous system; the importance of the nutritional factor contributing to the development of the syndrome of increased epithelial permeability and “dysbiosis” is shown. The importance of moderate physical activity and neurocognitive training in the prevention is demonstrated. It is concluded that the primary focus of prevention methods is to eliminate the influence of exogenous factors (reducing/eliminating the impact of pathogenic herbicides and pesticides, stress-induced conditions), modifying nutritional factors (rational and balanced nutrition), but also stimulating the physical and intellectual activity of patients.