顎口腔領域歯性感染症から分離されるＰｒｅｖｏｔｅｌｌａ属のβ‐ラクタマーゼ産生性とβ‐ラクタム系抗菌薬に対する感受性についての検討

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Orofacial odontogenic infections are usually treated with a β-lactam antibiotic. Most majorpathogens are susceptible to β-lactam antibiotics, although Prevotella species have been reported to produce β-lactamase and be resistant to β-lactam antibiotics. The purpose of this study was to evaluate β-lactamase production and antimicrobial susceptibility to 12 β-lactam antibiotics of Prevotella speciesisolated from 128 orofacial odontogenic infections. We confirmed that only Prevotella species were β-lactamasepositive in most isolates. Overall, 43.7% of pigmented Prevotella and 34.8% of nonpigmented Prevotella were positive for β-lactamase. The β-lactamase-positive strains were resistant to most of theantibiotics tested. However, piperacillin/tazobactam, cefmetazole, and faropenem showed antimicrobialactivity against these strains. In conclusion, this study shows the importance of β-lactamase-producing Prevotella strains in odontogenic infections and the need for appropriate choice of antibiotic.