Abstract
We recorded repeated caloric tests of 53 patients treated with streptomycin sulfate (SM) and measured the maximum slow phase velocity of caloric nystagmus.The maximum slow phase velocity often decreased below 10°/sec before the patient noted symptoms. However, it increased again above 10°/sec in one month when SM injections were stopped within 1 week after it had decreased below 10°/sec. On the other hand, no such increase was observed after 4 months of treatment. When it was above 10°/sec at the time of drug cessation, it showed no further change.These results suggest that 10°/sec of maximum slow phase velocity of caloric nystagmus is a critical level for the detection of subclinical functional damage of the vestibule in patients receiving SM injections but not complaining of subjective symptoms, and that this functional damage, if present, seems to be reversible with prompt discontinuation of SM injections.
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