Abstract
The effects of partial cystetomy, unilateral ureteric ligation, and transurethral injection of physiological saline on the induction of DNA synthesis in urinary bladder epithelium were studied in a total of 130 male F344 rats. DNA synthesis was evaluated by autoradiography and by immunohistochemical detection of bromodeoxyuridine labeled cells. DNA synthesis began to increase 12 hours after each treatment and reached a maximum at 24 to 48 hours with a mean labeling index of 15.8% (partial cystectomy; 48hrs), 1.9% (unilateral ureteric ligation; 24 hrs), 2.5% (1 injection of physiological saline; 24 hrs), and 5.2% (2 times injections of physiological saline; 36 hrs). The proliferative activity of bladder epithelial cells returned to normal 2 weeks after partial cystectomy, and 1 week after unilateral ureteric ligation or physiological saline injection.
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