Abstract
Pauson-Khand reaction (PKR) is a useful reaction for formation of cyclopentenones from alkyne-cobalt complex, which is obtained from alkynes and Co2 (CO) 8, and alkenes by heating the mixture or by treating the mixture with amine N-oxide at room temperature. Until now, there are many reports on PKR of both endo-cyclic and acyclic olefins, however, only a few reports on exo-olefins have appeared. Thus, the authors investigated intra- and inter-molecular PKR of exo-olefins. The intramolecular reaction of cyclic and acyclic enynes bearing exo-olefins was performed to give corresponding bi- and tri-cyclic compounds. Also, intermolecular PKR of exo-cyclic olefins with alkynes furnished spiro-bicyclic compounds. Furthermore, the present methodology was developed to construct tricyclic skeleton of Lycopodium alkaloid, magellanine family and formal total synthesis of magellanine was accomplished.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
