頭蓋内圧脈波の振動解析に関する研究 ２ シミュレーションによる動物実験データの解析

Abstract

To understand the relation between arterial pressure (AP) waves and intracranial pressure (ICP) pulse waves, animal experiments using adult cats and computer simulation using linear vibration model are conducted. In animal experiments, hypercapnias are performed. Equivalent compliance and equivalent mass are estimated by computer simulation using AP and ICP wave data measured by animal, experiment. During the increase of ICP at the beginning of experiments, the equivalent compliance decreases to low value and equivalent mass increases to high value. And when ICP returns to the initial low levels, the equivalent compliance and equivalent mass recover to the initial value. However, after several experiments, although ICP returns to low level, the equivalent compliance remains low value but equivalent mass recovers to low one. These results suggest that the compliance estimated by the computer simulation is available for the indicator of pathological changes in intracranial functions. And the increase of the equivalent mass is caused by that the flow rate of cerebrospinal fluid, which flows through narrow crevices in cranium, increases due to the rise of ICP. This phenomenon is verified by a vibration analysis of experimented results based on a dynamic model.