Abstract
The pathophysiologic mechanisms leading to endolymphatic hydrops in Meniere's disease are not well known. The changes in ionic permeability of cellular membranes between the endolymph and the perilymph, which can alter the inner ear fluid composition and its osmolarity, may be a major factor in the cause of Meniere's disease. In the present study, activities of endolymphatic K+, Na+, Cl- ([K+], [Na+], [Cl-]) and the endocochlear potential (EP) were measured by ion-selective microelectrodes while cochlear adenylate cyclase was intensively activated by perilymphatic perfusion with forskolin. We observed a rapid and marked increase in the [Cl-] activity and delayed decrease in the [K+] activity, accompanying an EP increase the onset of which was much slower than that of the increase in the [Cl-] activity. The results suggest that cochlear adenylate cyclase may play a major role in triggering the development of acute endolymphatic hydrops in attacks of Meniere's disease.
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