Abstract
Porous apatite was developed to make the best use of the advantages of the apatite, which are the good bone conductivity on the surface and the enhancement of the continuity of the new tissue by reducing the scope that the artificial material occupies as compared with the volume and extent of the bone defect. For the purpose of tapping the potentialities of the porous apatite as an artificial bone, we conducted an experiment on the implantation in the tibia. Sockets each measuring 6.6mm in diameter and 10mm in depth were made in the tibia of the adult dogs. Implanted cylindrical porous apatites (porosity rate: 50 to 70%), each 6.5mm in diameter and 10mm in length, were implanted and after sacrificing the dogs 5 to 90 days after implantation tissue specimens were made. Five days after the operation, almost all of the surrounding part of the porous apatite implanted in the substantia compacta and the inside of the pores were full of blood clot. In the substantia spongiosa, the formation of the bone tissue begins around the porous apatite and at the sametime the bone tissue forms over a wide area of the surface of the porous apatite. Three months after the operation, the pores in the substantia compacta are filled completely with compact bone. In the substantia spongiosa, a thick layer of the bone tissue covers the surface of the apatite and the pores are filled with a bone marrow tissue entirely similar to its surrounding.
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