Abstract
Because the drug-induced severe adverse reaction (SAR) is rare and often occur in the unexpected organs, the physician could be unfamiliar to SAR. In that case the early stage of the SAR is easy to overlook. So the Ministry of the Health and Welfare of Japan (MHLW) started the "Comprehensive project to deal with the disorders due to adverse drug reactions" as a four years plan since 2005. In this project, the MHLW published "the manual for handling disorders due to adverse drug reactions" in corporation with the academia. This manual is constituted by two parts, one is intended for the parents, and the other is for the general healthcare providers. In this article, the aim and the progress of the manuals and the brief summary of the SAR induced by the antibiotics will be explained. By the end of the June 2008, 29 manuals have been released, and 16 of them are antibiotics-related. It is needless to say that antibiotics are essential in the modern medical care, close monitoring of the symptom of SAR in untargeted organ is required in use of the antibiotics.
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