Abstract
Bisbenzylisoquinoline alkaloids of Stephania cepharantha have been used for various clinical purposes and recently reevaluated as stimulators of interleukin secretion in tissues. We analyzed molecular structures of bisbenzylisoquinoline alkaloids by determining their molecular weights using the 252Cf-plasma desorption mass spectrometry (PDMS) . The spectra were accumulated for 500000 fission events. The acceleration voltage used here was 15kV. Samples were analyzed using nitrocellulose-coated sample targets. Of the 5 alkaloids studied here, cepharanthine gave a main peak of molecular weight of 606.1 for the theoretical molecular weight of 606.7. The other minor peaks were considered to be demethylated fragment ions.252Cf-PDMS should be quite useful in studying structure, metabolism and pharmacokinetics of various drugs with extremely low coefficients of variation.
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