Abstract
Increased plasminogen activator (PA) secrection has been observed in transformed and malignant cells and PA is thought to be involved in the processes of invasion and metastasis. Recently both types of plasminogen activator such as tissue type PA (tPA) and urokinase type PA (uPA), have been detected in human plasma.In this study, to investigate the relationship between circulating PA and malignant state, we have measured plasma PA levels (PA activity, tPA and uPA antigen) in 69 women with gynecologic malignancies. These levels were compared to levels in a control group of 33 women with benign gynecologic tumors.In the case of uterine tumors, significantly higher levels of tPA antigen were measured in patients of stage IV with metastasis (p<0.05). In the case of ovarian tumors, significant higher levels of tPA antigen were measured in patients of stage III and stage IV who showed dissemenation or metastasis (p<0.01). There was no correlation between PA activity or uPA antigen levels and malignant state.These retults suggest that increased synthesis of tPA may play a role in cancer invasion and metastasis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
