実験的急性肝不全モデルに対するＬｉｐｏ ｐｒｏｓｔａｇｌａｎｄｉｎ Ｅ１の及ぼす影響

Abstract

When heat-killed Propionibacterium aches is intravenously injected into mice and seven days later, a small amount of gram-negative lipopolysaccharide (LPS) is also intravenously injected, most of the mice die of massive hepatic cell necrosis. However, when Lipo prostaglandin E1 was administered during this experimental induction of acute hepatic failue, the viability of the mice increased and the histological changes of the liver remarkably improved.These results suggested that Lipo prostaglandin E1 was effective in our experimental acute hepatic failure model. Since there is no difinite treatment method for fluminant hepatitis at present, Lipo prostaglandin E1 may be useful as a clinical treatment in future.