Abstract
Some organic fine chemicals have been developed by a combination of microbial and chemical processes. These combination processes make the production more simple, cost-effective, and environmentally friendly. The process of 6-chloro-3-aminomethylpyridine was established by incorporating the regioselective microbial hydroxylation of 3-cyanopyridine and the improved reduction of 6-chloro-3-cyanopyridine with modified Raney Nickel catalysts. Production of ethyl (R) -β-hydroxy-γ-cyanobutylate has been achieved via microbial asymmetric reduction of chloroacetoacetate. A novel method of 2-cyanopiperazine that includes a Michael addition of ethylenediamine to 2-chloroacrylonitrile, followed by an intramolecular cyclization, was found, and its application for the chiral piperazine derivatives via biotransformation is now under development.
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