Abstract
In this work, we tested the hypothesis that an agonist of nuclear X retinoid receptors, bexarotene, can improve impaired learning and memory in rats after prenatal hypoxia. Using the novel object recognition test paradigm, we analyzed the behavior of Wistar rats subjected to prenatal hypoxia on E14 (3 h, О2 7%), 7 and 30 days after a single intraventricular injection of bexarotene (4 µl, 10-2 М) on P20 compared to intact controls. Also, immunohistochemical analysis of the effect of bexarotene on the number of synaptopodin-positive dendritic spines in the СА1 field of the hippocampus, which decreases after prenatal hypoxia, has been performed. The bexarotene injection increases the number of labile dendritic spines in the hippocampus, enhances expression of a transport protein transthyretin in the choroid plexus of the lateral brain ventricles and improves memory in rats, subjected to prenatal hypoxia.
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