Корреляционные связи между TORCH-инфекцией и антифосфолипидными антителами при невынашивании беременности

Abstract

Objective. To study correlations between TORCH infections and antiphospholipid antibodies in spontaneous abortion. Patients and methods. We analysed 137 medical records of women with histories of abortion, who were divided into two groups according to the presence/absence of plasmapheresis in their treatment regimens at the stage of pregravid preparation with subsequent ranking to two subgroups according to the presence/absence of an active TORCH infection. Results. A moderate positive correlation was found between the levels of TORCH infection markers and IgМ against cardiolipin, IgМ against annexin V, IgМ against phospholipids. The maximal values of a strong positive correlation was noted in the pairs «TORCH – anticardiolipin IgG» as one of the most specific markers of antiphospholipid syndrome (APS) and «TORCH – antiphospholipid IgG» as the less specific antibodies, whose concentrations significantly increase in case of a TORCH infection, irrespective of the presence of APS. The presence of antibodies against a TORCH infection and correlations between them have shown a reciprocal relation between the markers of a TORCH infection and anticardiolipin IgG, anti-b2-glycoprotein-1 IgG, and TORCH – antiphospholipid IgG. Conclusion. TORCH infections are associated with higher titers of antiphospholipid antibodies, which in certain cases might lead to the appearance of the clinical symptoms of antiphospholipid syndrome. Key words: antiphospholipid antibodies, antiphospholipid syndrome, miscarriage, plasmapheresis, TORCH infection