ЭФФЕКТ АГОНИСТА РЕЦЕПТОРА TAAR5 СЛЕДОВЫХ АМИНОВ КАК МОДЕЛЬ ШИЗОФРЕНИИ ПО ДАННЫМ ЭЛЕКТРОКОРТИКОГРАФИИ КРЫС

Abstract

The effect of a-NETA, a TAAR5 trace amines receptor agonist, on ECOG was evaluated in chronic experiments in rats. Based of the role of gamma oscillations in the transmission of information between brain regions that is presumed to be affected by schizophrenia, the changes in the spatial synchronization in the gamma range, as well as the speciral power of the main ECoG rhythms, were separately estimated. In order to examine the topography of the entire cortex, 6 low-resistance electrodes were implanted in two rows of 3 in the cortex of both hemispheres of Adult Wistar male rats. Twenty experiments were performed: in 10 experiments, a-NETA was systemically administered, the saline was administered in other 10. Injection of a-NETA caused an increase in the power in the delta range of 0—5 Hz, coupled with a power reduction in the range of 5—10 Hz. The maximum differences were observed in the first 10 minutes. No differences were observed after the saline injections. The described growth of slow waves was accompanied by the decrease in the spatial synchronization of fast gamma-oscillations between all 6 registration points in comparison with the background before the injection, and with control. All effects were more pronounced for the anterior cortical areas. We suggest that a-NETA through effect on TAAR5 influences the dopamine transmission, which in turn disrupts the glutamatergic transmission, resulting in the gamma-synchronization dysfunction.