급성독성평가 및 종민감도분포(SSD)를 이용한 Florfenicol의 예측무영향농도(PNEC) 도출 및 비교

Abstract

Florfenicol, animal antibiotic, used in the respiratory and digestive treatment of cows, pigs, chickens, and fish. Antibiotics can have an adverse effect because 80 to 90 percent of antibiotics are released into the environment without decomposing in the body. In this study, we derived Predicted No Effect Concentration (PNEC) in two ways to study the effect of Florfenicol on the water system. Acute toxicity assessment was performed based on the OECD Test Guideline. The halfeffective concentrations (EC50) of algae (Pseudokirchneriella subcapotata) and water flea (Daphnia magna) were calculated as 2.3 mg/L (72 hr-EC50) and 384.3 mg/L (48 hr-EC50). PNECAF was derived as 2.3×10-3 mg/L by applying toxicity data of algae most sensitive to florfenicol. Species Sensitivity Distribution (SSD) was analyzed using L(E)C50 (10 species) values, and HC5 was 1.23 mg/L and PNECSSD was 0.2 mg/L. Comparing the two methods of PNEC, the value of PNECSSD was confirmed to be about 86 times higher than PNECAF. In risk assessment, it seems reasonable to approach the PNECSSD value.