Abstract
Department of Occupational and Environmental Medicine & Institute of Environmental and Occupational Medicine, Pusan Paik Hospital, Inje University, Pusan, KoreaABSTRACT Objectives: This study aimed to assess the concentration of perfluorooctanoic acid (PFOA) andperfluorooctanesulfonate (PFOS) in blood and factors controlling their exposure among Koreans. Methods: Study subjects were selected to include 718 members of the general population residing in fivemetropolitan cities and the Gangwon Province area from August 2008 to January 2009. A questionnaire wasadministered to investigate lifestyle, socio-demographic characteristics, and other related factors. Blood sampleswere collected and extracted using solid-phase extraction and anion-exchange methods, and quantified by high-performance liquid chromatograph (HPLC, Agilent 1200 Series) coupled with a Triple Quad LC-MS/MS system(Agilent 6410). Results: Geometric mean concentrations of PFOA and PFOS in the blood were measured as 1.82 and 6.06 ng/ml, respectively. Mean PFOA and PFOS concentrations generally increased with age in both genders. BloodPFOA concentration was significantly different according to such variables as age, family income, residentialdistrict, and province. Blood PFOS concentration was significantly different by such variables as gender, age,lifestyle factors such as regular exercise, alcohol consumption, and smoking status. Also, family income,hazardous facilities, job classification, and province contributed significantly to differences in blood PFOSconcentration levels.Conclusions: Blood PFOA and PFOS concentrations in Koreans were similar with those found in Japan, theUSA, and Germany, but less than those in Australia. PFOA and PFOS exposure seems to be affected by a varietyof factors in Korea. Therefore, investigation is required for each factor to assess the relative contribution ofdifferent variables. Keywords: perfluorooctanoic acid, perfluorooctane sulfonate, blood concentration, exposure control factors
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