Abstract
DL-β-methylaspartic acid was prepared and its two isomers separated. The more soluble erythro-form stimulated the growth ofEscherichia coli in a synthetic medium at a concentration of 1–5 μmoles/ml. The less soluble fraction containing the threo-form inhibited the growth ofEscherichia coli at the given concentrations. The growth inhibition was evidenced by a prolongation of the lag phase; the growth rate in the logarithmic phase and the maximum number of cells were not affected by the analogue. The inhibitory effect caused by the threo-form of β-methylaspartic acid could be suppressed by the addition of aspartic acid.
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