Abstract
In the article, in order to identify the role of mutations and polymorphisms of the endothelin-1 gene Lys198Asn in the development of COPD, the authors studied 49 patients with an established diagnosis of COPD. The control group consisted of 46 apparently healthy patients, comparable with the main group in terms of age and sex. The study of mutations and polymorphism of the endothelin-1 gene Lys198Asn was carried out by PCR, statistical analysis was carried out using the statistical software OpenEpi, Version 2.9. As a result, it was found that the heterozygous Lys / Asp genotype of the endothelin-1 gene Lys198Asn was found in the COPD group 1.25 times more often than in the control group. It was found that the mutational genotype Asp / Asp - was found in the COPD group 1.9 times more often than in the control group (RR 1.9, OR - 2.3; χ2 = 0.4), which indirectly shows the significance of changes in this gene in the development of COPD, and its course. The influence of the presence of a genotypic predisposition to endothelial dysfunction with its phenotypic manifestations was evaluated.
Published Version
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