Abstract
An efficient one-pot synthesis of the cis-pyridylimine palladium (II) complexes is reported. The compo- sition and structure were proved by NMR, IR, X-ray, and elemental analysis. The monoamine oxidase inhibition activity of synthesized complexes, including six complexes previously unknown, were inves- tigated on native mouse brains. Some of the synthesized compounds: cis-dichlorido-2,6-dimethyl-N- ((pyridin-2-yl)methylene)anilinepalladium(II), cis-dichlorido-4-nitro-N-((pyridin-2-yl)methylene)- anilinepalladium(II), and cis-dibromido-2,6-di(propan-2-yl)-N-((pyridin-2-yl)methylene)aniline- palladium(II) inhibited monoamine oxidase with moderate activity (IC50: 13.09–17.66 μМ). None of the studied compounds showed cytotoxic activity against HEK-293 cell line (human kidney embryonic cells). Acute systemic toxicity assay, that is conducted by intraperitoneal injection of cis-dichlorido-4- nitro-N-((pyridin-2-yl)methylene)anilinepalladium(II) indicated low toxicity (LD50> 5000 mg / kg) for outbred stocks mice. Bioavailability was assessed by logP’s measurement.
Highlights
PYRIDYLIMINE PALLADIUM(II) COMPLEXES: ONE-POT SYNTHESIS AND MONOAMINE OXIDASE INHIBITION An efficient one-pot synthesis of the cis-pyridylimine palladium (II) complexes is reported
That is conducted by intraperitoneal injection of cis-dichlorido-4nitro-N-((pyridin-2-yl)methylene)anilinepalladium(II) indicated low toxicity (LD50> 5000 mg / kg) for outbred stocks mice
(1999) “Synthesis and X‐ray Structures of New Mononuclear and Dinuclear Diimine Complexes of Late Transition Metals” European Journal of Inorganic Chemistry
Summary
Спектр ЯМР 1Н (ДМСО-d6, δ, м.д., J/Гц): 9.12 (дд, 1H, H-6′, J1 = 5.4, J2 =1.0); J/Гц): 9.13 (д, 1H, H-6′, J = 5.2); 8.73 (с, 1H, 8.62 (с, 1H, Hимина); 8.40 Спектр ЯМР 1Н (ДМСО-d6, δ, м.д., J/Гц): 9.14 (дд, 1H, C14H14Cl2N2Pd. Вычислено (%): C, 43.38; H, H-6′, J1 = 5.6, J2 = 0.8); 8.67 (с, 1H, Hимина); 3.64; N, 7.23. (0.075 мл, 0.4 ммоль) или (0.302 мл, 1.6 ммоль, Спектр ЯМР 13С (ДМСО-d6, δ, м.д.): 172.6; при четырехкратном увеличении). Спектр ЯМР 1Н (ДМСО-d6, δ, м.д., J/Гц): 9.13 Для определения активности МАО в 96-луночный черный планшет (SPL) вносят суспензию митохондрий по 100 мкл/лунка и инкубируют при 37°С в течение был образован из кинурамина, измеряют при длине волны излучения 380 нм и длине волны возбуждения 320 нм с помощью планшетного спектрофотометра FLUOstar Optima («BMG Labtech», Германия).
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